Journal de mycologie médicale
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There are no standard choices on antifungal drugs for talaromycosis due to various factors, and related studies are also limited. This study summarizes and analyzes efficacy of different antifungal drugs for patients with talaromycosis, which can provide more reference evidence for drugs' choices in practice. We conducted a meta-analysis on prognostic impacts of different antifungal drugs against talaromycosis, and primary outcome was all-cause mortality. ⋯ Initial treatment with amphotericin B for talaromycosis in different regions (internal and external) and studies (sample size<100) had no obvious prognostic advantages over itraconazole (RR: 0.60, 95% CI: 0.32-1.13; P=0.11; I2=44%; RR: 0.61, 95% CI: 0.37- 1.00; P=0.05; I2=0%; RR: 0.71, 95% CI: 0.39-1.29; P=0.26; I2=0%, respectively). However, when study's sample size was ≥ 100, the mortality of amphotericin B group was significantly reduced (RR: 0.54, 95% CI: 0.32- 0.92; P=0.02; I2=46%). In conclusion, amphotericin B is a better choice as initial therapeutic drug for talaromycosis.