Arthritis and rheumatism
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Arthritis and rheumatism · Feb 2002
Randomized Controlled Trial Multicenter Study Clinical TrialStructural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip.
To evaluate the structural effect of avocado/soybean unsaponifiables (ASU) in the treatment of patients with symptomatic osteoarthritis (OA) of the hip. ⋯ This pilot randomized, double-blind, placebo-controlled trial failed to demonstrate a structural effect of ASU in hip OA. However, in a post-hoc analysis, ASU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing. These results suggest that ASU could have a structural effect but require confirmation in a larger placebo-controlled study in hip OA.