Menopause : the journal of the North American Menopause Society
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Randomized Controlled Trial Multicenter Study
Measuring symptom relief in studies of vaginal and vulvar atrophy: the most bothersome symptom approach.
To assess the importance and usefulness of self-reported symptom data, especially the most bothersome symptom, in the evaluation of treatment for vulvovaginal atrophy. ⋯ : The most bothersome symptom approach represents a meaningful new standard for measurement of self-assessed vulvovaginal atrophy symptom change, but evaluation of change in individual symptoms remains an important, unbiased primary analysis of efficacy in vulvovaginal atrophy studies.