Biometrics
-
Review Clinical Trial
Adaptive treatment assignment methods and clinical trials.
This paper provides a general review of adaptive experimental designs which utilize accumulating information for assigning the best treatment to the most patients in clinical trials. The historical development of such methods is traced. ⋯ It is asserted that most published methods have important deficiencies that render them unsuitable for application. Suggestions are offered for reorienting this area of research into directions that are potentially more useful for clinical trials.