JNMA; journal of the Nepal Medical Association
-
JNMA J Nepal Med Assoc · Jan 2014
Randomized Controlled TrialOndansetron and Granisetron for prevention of postoperative nausea and vomiting following laparoscopic cholecystectomy.
Laparoscopic surgeries are known to be associated with a higher incidence of postoperative nausea and vomiting (PONV). Prophylaxis of PONV is usually achieved with a single-dose antiemetic drug administered during the surgical procedure. The aim of this study was to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, ondansetron and granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy. ⋯ Granisetron, when given prophylactically, resulted in a significantly lower incidence of PONV than ondansetron in the first 24 hours.