Academic radiology
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Comparative Study
Three-dimensional airway tree architecture and pulmonary function.
The airway tree is a primary conductive structure, and airways' morphologic characteristics, or variations thereof, may have an impact on airflow, thereby affecting pulmonary function. The objective of this study was to investigate the correlation between airway tree architecture, as depicted on computed tomography, and pulmonary function. ⋯ Despite the large variability in anatomic characteristics of the airway tree across subjects, architecture-based measures demonstrated statistically significant associations (P < .01) with nearly all pulmonary function testing measures, as well as with disease severity.
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To establish the range of normal for quantitative computed tomography (CT)-based measures of lung structure and function, we seek to develop methods for matching pulmonary structures across individuals and establishing a normative human lung atlas. ⋯ A computerized human lung atlas representing by the average shape of a population of twenty normal subjects was constructed and visualized. The atlas provides a basis for establishing regional ranges of normative values for structural and functional measures of the human lung. In the future, we plan to use the computerized human lung atlas to help detect and quantify early signs of lung pathology.
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To document the prevalence of coronary artery disease (CAD) and major adverse cardiac events (MACE) in patients younger than 45 years of age with intermediate pretest likelihood of CAD, and to determine whether coronary computed tomography angiography (cCTA) is useful for risk stratification of this cohort. ⋯ The prevalence of CAD and MACE in young adults with an intermediate pretest likelihood of CAD was considerable. cCTA is effective in restratifying patients into either a low or high posttest risk group. These results further emphasize the usefulness of cCTA in this cohort.
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For the evaluation of patients scheduled for the treatment of brain arteriovenous malformations (AVMs), accurate anatomical information is essential. The purpose of this study was to assess the usefulness of three-dimensional (3D) digital subtraction angiography (DSA)-magnetic resonance (MR) fusion imaging for the pretreatment evaluation of AVMs. ⋯ 3D DSA-MR fusion images are useful for the pretreatment evaluation of brain AVMs.
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Comparative Study
Liver fat quantification by dual-echo MR imaging outperforms traditional histopathological analysis.
The aim of this study was to evaluate the accuracy of dual-echo (DE) magnetic resonance imaging (MRI) with and without fat and water separation for the quantification of liver fat content (LFC) in vitro and in patients undergoing liver surgery, with comparison to histopathologic analysis. ⋯ DE MRI allows the accurate quantification of LFC in a surgical population, outperforming traditional histopathologic analysis. DE MRI without fat and water separation shows the highest accuracy and smallest measurement bias for the quantification of LFC.