Journal of investigative medicine : the official publication of the American Federation for Clinical Research
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Randomized Controlled Trial
Intensive therapy in newly diagnosed type 2 diabetes: results of a 6-year randomized trial.
This study aimed to assess the efficacy of early intensive diabetes therapy with either insulin plus metformin (INS) or triple oral therapy (TOT) with metformin, glyburide, and pioglitazone on glycemic control and A-cell function. ⋯ Early intensive treatment at the time of type 2 diabetes diagnosis-initial short-term insulin treatment followed by either insulin-based or intensive oral hypoglycemic-based therapy-stabilizes β-cell function for at least 6 years. Treatment failure was independent of intervention and was associated with worse disease pathology at baseline.