Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Jan 2012
Multicenter Study Clinical TrialNanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: an open-label trial.
Hereditary angioedema (HAE) is a rare disease caused by C1INH gene mutations, which leads to a deficiency or dysfunction of C1 inhibitor (C1 INH), resulting in recurrent episodes of severe and potentially life-threatening edema. ⋯ This open-label study demonstrates the efficacy and safety of C1 INH-nf for short-term treatment of HAE attacks.
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Ann. Allergy Asthma Immunol. · Dec 2011
Randomized Controlled Trial Multicenter StudyRandomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial.
The For Angioedema Subcutaneous Treatment (FAST)-3 study was a phase III, randomized, double-blind, placebo-controlled study of icatibant (bradykinin B(2) receptor antagonist) in subjects with hereditary angioedema (HAE) resulting from C1-INH deficiency or dysfunction (type I/II). ⋯ FAST-3 demonstrated that icatibant was effective and generally well tolerated in subjects with acute HAE attacks.
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Ann. Allergy Asthma Immunol. · Oct 2011
Comparative StudyComparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry.
Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects. ⋯ Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression.
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Ann. Allergy Asthma Immunol. · Sep 2011
Randomized Controlled TrialEfficacy of budesonide/formoterol pressurized metered-dose inhaler versus budesonide pressurized metered-dose inhaler alone in Hispanic adults and adolescents with asthma: a randomized, controlled trial.
Few clinical trials in asthma have focused on Hispanic populations. ⋯ Improvement in clinically relevant control end points occurred in both BUD/FM and BUD groups; both treatments were well tolerated in this Hispanic asthma population but were not significantly differentiated.