Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Jun 2003
Randomized Controlled Trial Comparative Study Clinical TrialConstruct validity and responsiveness of the Child Health Questionnaire in children with acute asthma.
To examine the validity and responsiveness of the Child Health Questionnaire (CHQ-PF28) in the context of acute exacerbation of asthma in children. ⋯ Both the physical and psychosocial subscales of the CHQ-PF28 administered 14 days after an ED visit for acute exacerbation of asthma are correlated with poor short-term functional outcome, but scores are only moderately responsive to acute changes in functional status.
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Ann. Allergy Asthma Immunol. · Jul 2002
Randomized Controlled Trial Clinical TrialA randomized, double-blind trial of the effect of treatment with formoterol on clinical and inflammatory parameters of asthma in children.
In addition to their bronchodilating effect, long-acting inhaled beta-agonists have recently been shown to have some anti-inflammatory properties. ⋯ These results indicate that formoterol has measurable anti-inflammatory properties and can diminish asthma symptoms and bronchial hyperreactivity.
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Ann. Allergy Asthma Immunol. · Jun 2002
Randomized Controlled Trial Multicenter Study Clinical TrialEfficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial performed in the fall.
Histamine and cysteinyl leukotrienes seem to be important mediators of allergic rhinitis. ⋯ Montelukast alone or in combination with loratadine is well tolerated and provides clinical and quality-of-life benefits for patients with seasonal allergic rhinitis.
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Ann. Allergy Asthma Immunol. · Jul 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.
There are no studies on the use of cetirizine in children under the age of 6. ⋯ The results of the present study suggest that cetirizine may represent an effective and safe pharmacologic therapy for chronic urticaria in preschool children. There was no evidence for changes in hematochemical and urinary values, demonstrating the safety and the tolerability of the two antihistamines, even when given to young children.
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Ann. Allergy Asthma Immunol. · Jun 2001
Randomized Controlled Trial Multicenter Study Clinical TrialOnce-daily budesonide via Turbuhaler improves symptoms in adults with persistent asthma.
Previous studies have demonstrated the efficacy and safety of twice-daily budesonide Turbuhaler (Pulmicort Turbuhaler, AstraZeneca, Wilmington, DE) for the treatment of mild to severe asthma. ⋯ Budesonide Turbuhaler 400 microg administered once daily in the AM is efficacious and safe for inhaled corticosteroid-naive asthmatic adults.