Experimental neurology
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Experimental neurology · Nov 2013
Randomized Controlled TrialAntidepressant effects after short-term and chronic stimulation of the subgenual cingulate gyrus in treatment-resistant depression.
Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Apart from its potential long-term antidepressant effects acute stimulation effects have been described. We investigated putative neuroanatomical clusters in which such acute effects accumulate and followed patients over the long-term. ⋯ Our results confirm that stimulation of the SCG is capable of exerting moderate acute and chronic antidepressant effects. The predictive value of these findings needs to be addressed in future studies.