European journal of neurology : the official journal of the European Federation of Neurological Societies
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Randomized Controlled Trial Clinical Trial
Effect of gabapentin on oculomotor control and parkinsonism in patients with progressive supranuclear palsy.
The efficacy of gabapentin on motor, oculomotor and frontal lobe symptoms was evaluated in patients with progressive supranuclear palsy (PSP) in a pilot study. Fourteen patients were included and seven of them received gabapentin. ⋯ However, the error rate in the antisaccade task was significantly decreased in the gabapentin group. This preliminary study shows that gabapentin improves reflexive saccade inhibition in patients with PSP but does not improve the latency of VGSs.