European journal of neurology : the official journal of the European Federation of Neurological Societies
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Editorial Comment
Is post-traumatic headache classifiable and does it exist?
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Randomized Controlled Trial Comparative Study
Subcutaneous histamine versus botulinum toxin type A in migraine prophylaxis: a randomized, double-blind study.
To compare the efficacy and tolerability of the subcutaneous administration of histamine and botulinum toxin type A (BoNTA) in migraine prophylaxis. ⋯ This randomized study demonstrated that both histamine and BoNTA are similarly effective and well tolerated in reducing or eliminating headache in migraine prophylaxis. Low doses of histamine applied subcutaneously may represent a novel and effective therapeutic alternative in migraine patients and lay the clinical and pharmacological groundwork for the use of H3 agonist in migraine prophylaxis.