European journal of neurology : the official journal of the European Federation of Neurological Societies
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Review Meta Analysis
The efficacy of temozolomide for recurrent glioblastoma multiforme.
The efficacy of temozolomide (TMZ) in recurrent glioblastoma multiforme (GBM) has been evaluated by several clinical trials. A meta-analysis to assess the overall efficacy of TMZ in the treatment of recurrent GBM was carried out by the authors. ⋯ Temozolomide is effective for recurrent GBMs, and its efficacy may be increased with metronomic schedule and high average daily dose (>100 mg/m(2) ).