European journal of neurology : the official journal of the European Federation of Neurological Societies
-
Review Meta Analysis
The adverse event profile of perampanel: meta-analysis of randomized controlled trials.
To identify adverse events (AEs) significantly associated with perampanel treatment in double-blind clinical studies (RCTs). Serious AEs, study withdrawals due to AEs and dose-effect responses of individual AEs were also investigated. ⋯ Vestibulocerebellar AEs (dizziness, ataxia), sedative effects (somnolence), irritability and weight increase were significantly associated with perampanel treatment.