Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
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J. Interferon Cytokine Res. · Jan 2014
ReviewThe significance and regulatory mechanisms of innate immune cells in the development of sepsis.
Sepsis with subsequent multiple organ dysfunction is a pronounced systemic inflammatory response to concealed or known infection and is a leading cause of death in intensive care units. The survival rate of severe sepsis and septic shock has not markedly improved in recent decades despite a great number of receptors and molecules involved in its pathogenesis have been found and taken as therapeutic targets. ⋯ Therefore, an understanding of the biological significance and pathophysiological roles of different cell populations might gain novel insights into the immunoregulatory mechanisms of sepsis. In this review, we focus on major immune cells that may play potential roles in the contribution of new therapeutic approaches for sepsis.