Inflammation research : official journal of the European Histamine Research Society ... [et al.]
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Randomized Controlled Trial Clinical Trial
Premedication with H1 and H2 blocking agents reduces the incidence of postoperative nausea and vomiting.
Patients undergoing anaesthesia and surgery frequently complain about postoperative nausea and vomiting (PONV). Whether pretreatment with H1 and H2 blocking agents reduces the incidence of PONV remains controversial. To answer this question, we performed a randomised, prospective, placebo-controlled clinical study to evaluate the efficacy of a premedication with H1 and H2 receptor antagonists. ⋯ Premedication with H1 and H2 blocking agents significantly reduces the incidence of postoperative nausea and vomiting.