Inflammatory bowel diseases
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Inflamm. Bowel Dis. · Dec 2012
Review Meta AnalysisAnti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis.
Anti-tumor necrosis factor (TNF) antibodies are efficacious in patients with Crohn's disease (CD) but the influence of these medications on surgical outcomes in CD patients has been frequently debated. The aim was to evaluate the impact of preoperative treatment with anti-TNF antibodies on postoperative complications in CD patients undergoing abdominal surgery. ⋯ Preoperative infliximab treatment is associated with an increased risk of postoperative infectious complications, mostly nonlocal. A trend toward an increased risk of noninfectious and overall complications was also observed.