Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
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J Trace Elem Med Biol
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J Trace Elem Med Biol · Jan 2015
Randomized Controlled TrialBiomarkers in critically ill patients with systemic inflammatory response syndrome or sepsis supplemented with high-dose selenium.
Low levels of selenium (Se) and glutathione peroxidase (GSHPx), a key selenoenzyme, were documented in systemic inflammatory response syndrome (SIRS) and sepsis, both associated with high mortality. Se supplementation had mixed effects on outcome. We hypothesized that Se supplementation could have a different impact on biomarkers and 28-day mortality in patients with SIRS vs. sepsis. ⋯ Se levels correlated with GSHPx activity and other nutritional biomarkers with significant differences between SIRS and sepsis groups. High-dose Se supplementation did not affect mortality but a strong trend to decreased mortality in SIRS patients warrants further studies in this population.