Multiple sclerosis : clinical and laboratory research
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Multicenter Study
Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration.
Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. ⋯ Long-term physical disability was independently linked with atrophy of the spinal cord and brain T2 lesion load, and less consistently, with brain grey matter atrophy. Combinations of spinal cord and brain MRI measures may be required to capture clinically-relevant information in people with MS of long disease duration.