European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
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Eur J Vasc Endovasc Surg · Jan 2011
Randomized Controlled Trial Multicenter StudyComparison of surveillance versus aortic endografting for small aneurysm repair (CAESAR): results from a randomised trial.
Randomised trials have failed to demonstrate benefit from early surgical repair of small abdominal aortic aneurysm (AAA) compared with surveillance. This study aimed to compare results after endovascular aortic aneurysm repair (EVAR) or surveillance in AAA <5.5 cm. ⋯ This study is registered, NCT Identifier: NCT00118573.
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Eur J Vasc Endovasc Surg · Jun 2010
Randomized Controlled Trial Multicenter Study Comparative StudyPTFE bypass to below-knee arteries: distal vein collar or not? A prospective randomised multicentre study.
Patency and limb salvage after synthetic bypass to the arteries below-knee are inferior to that which can be achieved with autologous vein. Use of a vein collar at the distal anastomosis has been suggested to improve patency and limb salvage, a problem that is analysed in this randomised clinical study. ⋯ This study failed to show any benefit for vein collar with PTFE bypass to a below-knee artery.
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Eur J Vasc Endovasc Surg · May 2010
Randomized Controlled Trial Multicenter Study Comparative StudyRandomised clinical trial comparing endovenous laser ablation with stripping of the great saphenous vein: clinical outcome and recurrence after 2 years.
This study aims to compare the outcome 2years after treatment of varicose veins by endovenous laser ablation (EVLA) or surgery by assessing recurrence, venous clinical severity score (VCSS) and quality of life. ⋯ No significant differences in clinical or ultrasound recurrences were found between EVLA and surgery groups. Our study also shows that similar improvements in clinical severity scores and quality of life were gained in both treatments.
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Eur J Vasc Endovasc Surg · Jun 2009
Randomized Controlled Trial Comparative StudyLow molecular weight heparin significantly reduces embolisation after carotid endarterectomy--a randomised controlled trial.
The administration of unfractionated heparin (UFH) prior to carotid clamping during carotid endarterectomy (CEA) transiently increases the platelet aggregation response to arachidonic acid (AA) despite the use of aspirin. We hypothesized that this phenomenon might be reduced by using low molecular weight heparin (LMWH) resulting in fewer emboli in the early post-operative period. ⋯ Intravenous LMWH is associated with a significant reduction in post-operative embolisation without increased bleeding. The higher rate of embolisation seen with UFH may be mediated by increased platelet aggregation to ADP, rather than to AA.
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Eur J Vasc Endovasc Surg · May 2009
Randomized Controlled Trial Comparative StudyCombined aspirin and cilostazol treatment is associated with reduced platelet aggregation and prevention of exercise-induced platelet activation.
Cilostazol has proven efficacy in increasing walking distance in claudicants, but it has not been demonstrated to be more effective than placebo in secondary cardiovascular prevention. The direct effect of exercise on platelet function remains less well defined. We have investigated the effect of combination treatment with aspirin and cilostazol on platelet activity in claudicants subjected to repeated treadmill exercise. ⋯ Combination treatment with aspirin and cilostazol results in suppression of platelet activation and reduces the effect of exercise on platelets. The benefit seen may be a result of cilostazol enhancing the inhibitory effect of aspirin on the cyclo-oxygenase pathway.