Allergy and asthma proceedings :
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Allergy Asthma Proc · Jul 2017
ReviewEfficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: A systematic literature review.
There are limited pediatric data about the use of omalizumab, especially the effectiveness and safety of omalizumab in the real-world management of allergic asthma. ⋯ Overall, RCT evidence strongly supported omalizumab efficacy and safety as add-on treatment in children 6 to 11 years old with moderate-to-severe persistent allergic asthma. RWS data confirmed these findings in an extended patient population of children and adolescents that is more generalizable to the actual day-to-day management of these patients.
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Allergy Asthma Proc · Jul 2017
ReviewEfficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: A systematic literature review.
There are limited pediatric data about the use of omalizumab, especially the effectiveness and safety of omalizumab in the real-world management of allergic asthma. ⋯ Overall, RCT evidence strongly supported omalizumab efficacy and safety as add-on treatment in children 6 to 11 years old with moderate-to-severe persistent allergic asthma. RWS data confirmed these findings in an extended patient population of children and adolescents that is more generalizable to the actual day-to-day management of these patients.
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Allergy Asthma Proc · Nov 2016
Meta AnalysisMeasures to reduce maintenance therapy with oral corticosteroid in adults with severe asthma.
Maintenance therapy with oral corticosteroid (OCS) is used, although not based on evidence, for patients with severe asthma, but OCS is associated with serious adverse effects; therefore, management strategies aimed at steroid sparing are important. ⋯ In adults with severe asthma, several corticosteroid-sparing interventions were shown to be effective in reducing systemic steroid exposure, not least in studies of add-on biologic therapy. However, based on the available studies, ciclesonide, based on the low potential for systemic effect, especially seems to be a good candidate for reducing steroid exposure in these patients before possible initiation of biologic therapy.
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Allergy Asthma Proc · Mar 2016
Review Case Reports Meta AnalysisApproach to evaluation and management of a patient with multiple food allergies.
Diagnosing food allergy is often challenging, and validated testing modalities are mostly limited to immunoglobulin E (IgE)-mediated reactions to foods. Use of food-specific IgE tests and skin prick tests in individuals without a history that supports an IgE-mediated reaction to the specific food being tested diminishes the predictive capabilities of the test. ⋯ An evidence-based approach to diagnosing and managing a patient at risk of having a life-threatening food allergy is reviewed.
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Allergy Asthma Proc · Sep 2015
ReviewUpdate on the utility of corticosteroids in acute pediatric respiratory disorders.
Corticosteroids, delivered systemically and by inhalation, are widely used for the treatment of multiple acute respiratory illnesses in children. However, the level of evidence to support the utility of this therapy varies between these different acute respiratory illnesses. ⋯ Corticosteroids treatment response varies between the acute respiratory illnesses presented in this review. Future research should aim to fill the current gaps-of-knowledge regarding the utility this intervention such as the identification of specific wheezing phenotypes among preschool children which might benefit from systemic corticosteroids as a treatment for acute viral wheeze.