Annals of internal medicine
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Randomized Controlled Trial Clinical Trial
Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study.
To determine whether correction of acidemia using bicarbonate improves hemodynamics in patients who have lactic acidosis. ⋯ Correction of acidemia using sodium bicarbonate does not improve hemodynamics in critically ill patients who have metabolic acidosis and increased blood lactate or the cardiovascular response to infused catecholamines in these patients. Sodium bicarbonate decreases plasma ionized calcium and increases PaCO2.