Annals of internal medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of Pneumocystis pneumonia and toxoplasmosis in patients infected with HIV.
To evaluate the efficacy and safety of two oral, intermittent drug regimens for the simultaneous primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmosis in patients with HIV infection. ⋯ Thrice-weekly trimethoprim-sulfamethoxazole is an effective and well-tolerated regimen for the simultaneous primary prophylaxis of P. carinii pneumonia and toxoplasmosis in patients infected with HIV. Twice-weekly dapsone-pyrimethamine appears to be a safe and effective alternative.
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Comparative Study
The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia.
To assess the safety of minibronchoalveolar lavage done by respiratory therapists for the evaluation of suspected ventilator-associated pneumonia and to determine the diagnostic agreement between quantitative lower airway cultures obtained by the minibronchoalveolar lavage and protected specimen brush techniques. ⋯ Minibronchoalveolar lavage is a safe and technically simple procedure for obtaining quantitative lower airway cultures in patients requiring mechanical ventilation. Quantitative culture results obtained by minibronchoalveolar lavage are similar to those obtained by the protected specimen brush technique.