Annals of internal medicine
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Meta Analysis Comparative Study
Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis.
To compare luteinizing hormone-releasing hormone (LHRH) agonists with orchiectomy or diethylstilbestrol, and to compare antiandrogens with any of these three alternatives. ⋯ Survival after therapy with an LHRH agonist was equivalent to that after orchiectomy. No evidence shows a difference in effectiveness among the LHRH agonists. Survival rates may be somewhat lower if a nonsteroidal antiandrogen is used as monotherapy.