Annals of internal medicine
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Biography Historical Article
Endocrine and autoimmune aspects of the health history of John F. Kennedy.
At the age of 43 years, John F. Kennedy was the youngest man ever elected president. ⋯ The recent opening of his White House medical records has provided researchers greater insight into the multiple medical conditions that afflicted Kennedy. A recent review of these records, coupled with other available sources, allows new understanding of his health history that can now be explained in the context of a unifying autoimmune endocrine disorder.
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Guidelines recommend warfarin use in patients with atrial fibrillation solely on the basis of risk for ischemic stroke without antithrombotic therapy. These guidelines rely on ischemic stroke rates observed in older trials and do not explicitly account for increased risk for hemorrhage. ⋯ National Institute on Aging; National Heart, Lung, and Blood Institute; and Massachusetts General Hospital.