Annals of internal medicine
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The functional and quality-of-life benefits of transcatheter aortic valve replacement (TAVR) have not been established. ⋯ Transcatheter aortic valve replacement provides clinically important benefits in physical function and disease-specific measures of quality of life but modest benefits in psychological and general health measures. More comparative studies on functional status and quality of life are needed for informed treatment decision making.
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The functional and quality-of-life benefits of transcatheter aortic valve replacement (TAVR) have not been established. ⋯ Transcatheter aortic valve replacement provides clinically important benefits in physical function and disease-specific measures of quality of life but modest benefits in psychological and general health measures. More comparative studies on functional status and quality of life are needed for informed treatment decision making.
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Mutations in breast cancer susceptibility genes (BRCA1 and BRCA2) are associated with increased risks for breast, ovarian, and other types of cancer. ⋯ Studies of risk assessment, genetic counseling, genetic testing, and interventions to reduce cancer and mortality indicate potential benefits and harms that vary according to risk.
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Mutations in breast cancer susceptibility genes (BRCA1 and BRCA2) are associated with increased risks for breast, ovarian, and other types of cancer. ⋯ Studies of risk assessment, genetic counseling, genetic testing, and interventions to reduce cancer and mortality indicate potential benefits and harms that vary according to risk.
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Review Meta Analysis
Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis.
Performance characteristics of fecal immunochemical tests (FITs) to screen for colorectal cancer (CRC) have been inconsistent. ⋯ National Institute of Diabetes and Digestive and Kidney Diseases and National Cancer Institute.