Annals of internal medicine
-
Randomized Controlled Trial Multicenter Study
The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin-Detected Pregnancy, Pregnancy Loss, and Live Birth : Per Protocol Analysis of a Randomized Trial.
A previous large randomized trial indicated that preconception-initiated low-dose aspirin (LDA) therapy did not have a positive effect on pregnancy outcomes. However, this trial was subject to nonadherence, which was not taken into account by the intention-to-treat approach. ⋯ National Institutes of Health.
-
Randomized Controlled Trial Multicenter Study
The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt : A Randomized Controlled Trial.
The efficacy of rifaximin in the secondary prevention of overt hepatic encephalopathy (HE) is well documented, but its effectiveness in preventing a first episode in patients after transjugular intrahepatic portosystemic shunt (TIPS) has not been established. ⋯ French Public Health Ministry.
-
Randomized Controlled Trial Multicenter Study
A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study of Ad26.ZIKV.001, an Ad26-Vectored Anti-Zika Virus Vaccine.
Zika virus (ZIKV) may cause severe congenital disease after maternal-fetal transmission. No vaccine is currently available. ⋯ Janssen Vaccines and Infectious Diseases.
-
Multicenter Study Observational Study
Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.
Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19). ⋯ None.
-
Multicenter Study
Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.
The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. ⋯ Agency for Healthcare Research and Quality.