Annals of internal medicine
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Comment Randomized Controlled Trial
In low-risk penicillin allergies, direct oral challenge was noninferior to skin testing followed by oral challenge.
Copaescu AM, Vogrin S, James F, et al. Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial. JAMA Intern Med. 2023;183:944-952. 37459086.
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Randomized Controlled Trial
Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial.
Mild cognitive impairment (MCI) negatively impacts cognition and dual-task abilities. A physical-cognitive integrated treatment approach could mitigate this risk for dementia. ⋯ National Institute on Aging.
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Randomized Controlled Trial Pragmatic Clinical Trial
Effect of Complementary Interventions to Redesign Care on Teamwork and Quality for Hospitalized Medical Patients : A Pragmatic Controlled Trial.
Multiple challenges impede interprofessional teamwork and the provision of high-quality care to hospitalized patients. ⋯ Agency for Healthcare Research and Quality.
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Comment Randomized Controlled Trial Multicenter Study
In adults with BMI ≥27 kg/m2 and type 2 diabetes, adding tirzepatide to a lifestyle intervention increased weight loss at 72 wk.
Garvey WT, Frias JP, Jastreboff AM, et al; SURMOUNT-2 investigators. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023;402:613-626. 37385275.
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Comment Randomized Controlled Trial
In healthy older adults, low-dose aspirin did not differ from placebo for ischemic stroke but increased intracranial bleeding.
Cloud GC, Williamson JD, Thao LTP, et al. Low-dose aspirin and the risk of stroke and intracerebral bleeding in healthy older people: secondary analysis of a randomized clinical trial. JAMA Netw Open. 2023;6:e2325803. 37494038.