Annals of surgery
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Randomized Controlled Trial Clinical Trial
Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns.
Two forms of recombinant growth hormone that accelerate the healing of skin graft donor sites in severely burned children were evaluated. ⋯ Our results indicate that both forms of rhGH are effective in reducing donor site healing time compared with placebo and suggest that accelerating wound healing is of clinical benefit because the patients' own skin becomes rapidly available for harvest and autografting. With this increase in the rate of wound healing, the total length of hospital stay can be reduced by more than 25%.