Annals of surgery
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To evaluate the pathogenesis of metaplastic processes within the esophagus using a human model in which the exact duration of reflux was known. ⋯ Esophageal columnar metaplasia is a common complication after gastric pull-up esophagectomy. Metaplasia is more likely to develop in patients with previous BE than other patients. Metaplasia develops in response to squamous epithelial injury in predisposed individuals.
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Randomized Controlled Trial Comparative Study Clinical Trial
Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial.
To compare the results of open versus laparoscopic repair for perforated peptic ulcers. ⋯ Laparoscopic repair of perforated peptic ulcer is a safe and reliable procedure. It was associated with a shorter operating time, less postoperative pain, reduced chest complications, a shorter postoperative hospital stay, and earlier return to normal daily activities than the conventional open repair.
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To compare laparoscopic with open hernia repair in a randomized clinical trial at a median follow-up of 5 years. ⋯ These data show a similar outcome for laparoscopic and open hernia repair, and both procedures have a place in managing this common problem.
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To elucidate the metabolic changes occurring within hepatocytes during acute phase reaction and liver regeneration. ⋯ These findings indicate that changes in liver metabolism after surgery reflect the magnitude of tissue injury and the quantity of functioning liver cells. Acute phase responses dominate the initial recovery period at the expense of less important endergonic functions. When liver parenchyma is lost, the acute phase reaction is maintained and further supported by a rapid replenishment of hepatocytes, which can even be considered a continuation of acute phase physiology. Modulation of liver function within the framework of overall hepatic energy economy is one mechanism for matching energy supply with increased demands during these processes.
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To audit the results of endoscopic transanal resection of tumor (ETAR) performed by a single surgeon at a specialized colorectal unit during a 10- year period. ⋯ Endoscopic transanal resection of tumor is safe and effective and offers successful palliation or definitive treatment of rectal lesions with low rates of death and complications when performed by a dedicated surgeon.