Annals of surgery
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial.
To investigate the effect of a restricted intravenous fluid regimen versus a standard regimen on complications after colorectal resection. ⋯ The restricted perioperative intravenous fluid regimen aiming at unchanged body weight reduces complications after elective colorectal resection.
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We have previously demonstrated that P. aeruginosa can have profound effects on the intestinal epithelial barrier via one of its virulence factors, the PA-I lectin/adhesin. The aims of the present study were to further characterize the interaction of P. aeruginosa and the intestinal epithelium using both in vitro and in vivo approaches. ⋯ These data indicate that multiple factors present in the intestinal microenvironment of a stressed host may induce certain opportunistic pathogens to express key virulence factors leading to a state of lethal gut-derived sepsis.
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Randomized Controlled Trial Clinical Trial
Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial.
To determine the effects of preoperative dexamethasone on surgical outcome after laparoscopic cholecystectomy (LC). ⋯ Preoperative dexamethasone (8 mg) reduced pain, fatigue, nausea and vomiting, and duration of convalescence in patients undergoing noncomplicated LC, when compared with placebo, and is recommended for routine use.
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Randomized Controlled Trial Clinical Trial
Gallstone formation prophylaxis after gastric restrictive procedures for weight loss: a randomized double-blind placebo-controlled trial.
To determine if a 6-month regimen of prophylactic ursodeoxycholic acid is effective in the prevention of gallstones. ⋯ A daily dose of 500 mg of ursodeoxycholic acid for 6 months is effective prophylaxis for gallstone formation following gastric restrictive procedures.