Annals of surgery
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Multicenter Study
Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients.
To determine the effect of blood component ratios in massive transfusion (MT), we hypothesized that increased use of plasma and platelet to red blood cell (RBC) ratios would result in decreased early hemorrhagic death and this benefit would be sustained over the ensuing hospitalization. ⋯ Current transfusion practices and survival rates of MT patients vary widely among trauma centers. Conventional MT guidelines may underestimate the optimal plasma and platelet to RBC ratios. Survival in civilian MT patients is associated with increased plasma and platelet ratios. Massive transfusion practice guidelines should aim for a 1:1:1 ratio of plasma:platelets:RBCs.
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Multicenter Study
A national US study of posttraumatic stress disorder, depression, and work and functional outcomes after hospitalization for traumatic injury.
To examine factors other than injury severity that are likely to influence functional outcomes after hospitalization for injury. ⋯ PTSD and depression occur frequently and are independently associated with enduring impairments after injury hospitalization. Early acute care interventions targeting these disorders have the potential to improve functional recovery after injury.