Annals of surgery
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There is limited data on the appropriate management of dysplasia in Crohn's colitis. An evidence-based surgical strategy is provided. ⋯ The findings confirm the risk of cancer in patients with CD dysplasia. Because of the multifocal nature of dysplasia in Crohn's colitis, TPC is recommended in good-risk patients. In specific circumstances, such as poor-risk patients especially in the setting of LGD, close endoscopic surveillance or alternatively segmental or STC with close postoperative endoscopic surveillance, depending upon the individual circumstance, may be discussed.
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To investigate the antibacterial effect of augmenting a biological dressing with polymer films containing silver nanoparticles. ⋯ The results of our study indicate that immobilizing silver-impregnated PEMs on the wound-contact surface of Biobrane significantly reduces bacterial bioburden in full-thickness murine skin wounds. Further research will investigate whether this construct can be considered for human use.