Annals of surgery
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Randomized Controlled Trial
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
To test whether simvastatin improves physiological and biological outcomes in patients undergoing esophagectomy. ⋯ In this proof of concept study, pretreatment with simvastatin in esophagectomy decreased biomarkers of inflammation as well as pulmonary epithelial and systemic endothelial injury.
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Defining processes of care, which are appropriate and necessary for management of gastric cancer (GC), is an important step toward improving outcomes. ⋯ The expert panel has created 22 statements for the perioperative management of GC patients, to provide guidance to clinicians and improve the care received by patients.
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To explore the hypothesis that decreased arginine availability by myeloid-derived suppressor cells (MDSCs) is a cause of T-cell dysfunction after physical injury (PI). ⋯ Arginine availability is decreased after PI coinciding with an induction of MDSC expressing arginase 1. Decreased arginine may inhibit T-cell function and increase susceptibility to infection after injury.
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Review Meta Analysis
Preoperative smoking status and postoperative complications: a systematic review and meta-analysis.
To systematically review and summarize the evidence of an association between preoperative smoking status and postoperative complications elaborated on complication type. ⋯ Preoperative smoking was found to be associated with an increased risk of the following postoperative complications: general morbidity, wound complications, general infections, pulmonary complications, neurological complications, and admission to the intensive care unit.