Annals of surgery
-
Meta Analysis Comparative Study
Comparison of treatment effect estimates from prospective nonrandomized studies with propensity score analysis and randomized controlled trials of surgical procedures.
We aimed to compare treatment effect estimates from NRSs with PS analysis and RCTs of surgery. ⋯ There was no statistically significant difference in treatment effect between NRSs with PS analysis and RCTs. Prospective NRSs with suitable and careful PS analysis can be relied upon as evidence when RCTs are not possible.
-
Randomized Controlled Trial
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
To test whether simvastatin improves physiological and biological outcomes in patients undergoing esophagectomy. ⋯ In this proof of concept study, pretreatment with simvastatin in esophagectomy decreased biomarkers of inflammation as well as pulmonary epithelial and systemic endothelial injury.