Annals of surgery
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Multicenter Study
The Outcomes and Patterns of Treatment Failure After Surgery for Locally Recurrent Rectal Cancer.
To assess the outcomes and patterns of treatment failure of patients who underwent pelvic exenteration surgery for recurrent rectal cancer. ⋯ R0 resection of the pelvic recurrence is the most significant factor affecting overall and disease-free survival. The surgery is complex and often highly morbid, and where possible patients should be given perioperative chemoradiotherapy. Further investigations are required to determine the role of adjuvant chemotherapy.