Annals of surgery
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Randomized Controlled Trial Multicenter Study
Pelvic Floor Rehabilitation After Rectal Cancer Surgery: A Multicentre Randomised Clinical Trial (FORCE Trial).
To investigate the effects of PFR after LAR compared to usual care without PFR. ⋯ No benefit was found of PFR in all patients but several subgroups were identified that did benefit from PFR, such as patients with urgency or with at least moderate incontinence and no near-complete incontinence. A selective referral policy (65%-85% of all patients) is suggested to improve postoperative functional outcomes for patients after LAR for rectal cancer.
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We conducted the first prospective clinical trial of neoadjuvant chemotherapy for patients with obstructive colon cancer. ⋯ Neoadjuvant chemotherapy using mFOLFOX6 was feasible and might be a treatment option for patients with obstructive colon cancer. Further large-scale studies are warranted to confirm the present findings.
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Multicenter Study
Surgical Treatment after Neoadjuvant Systemic Therapy in Young Women with Breast Cancer: Results from a Prospective Cohort Study.
We aimed to investigate eligibility for breast conserving surgery (BCS) pre- and post-neoadjuvant systemic therapy (NST), and trends in the surgical treatment of young breast cancer patients. ⋯ While the proportion of young women eligible for BCS increased after NST, many patients chose mastectomy, suggesting that surgical decisions are often driven by factors beyond extent of disease and treatment response.