Annals of surgery
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Randomized Controlled Trial Multicenter Study
A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.
To test by randomized prospective multicenter trial the hypothesis that pancreaticoduodenectomy (PD) without the use of intraperitoneal drainage does not increase the frequency or severity of complications. ⋯ This study provides level 1 data, suggesting that elimination of intraperitoneal drainage in all cases of PD increases the frequency and severity of complications.
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Randomized Controlled Trial Multicenter Study Comparative Study
A randomized study on 1-week versus 4-week prophylaxis for venous thromboembolism after laparoscopic surgery for colorectal cancer.
To compare the efficacy and safety of antithrombotic prophylaxis given for 1 week or 4 weeks in patients undergoing laparoscopic surgery for colorectal cancer. ⋯ After laparoscopic surgery for colorectal cancer, extended antithrombotic prophylaxis is safe and reduces the risk for VTE as compared with 1-week prophylaxis (NCT01589146).
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Randomized Controlled Trial Multicenter Study
Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperative ileus.
To identify clinical hallmarks associated with recovery of gastrointestinal transit. ⋯ Our data indicate that the time to SF + D best reflects recovery of gastrointestinal transit and therefore should be considered as primary outcome measure in future clinical trials on postoperative ileus.(Netherlands National Trial Register, number NTR1884 and NTR222).
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Multicenter Study
Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION) Therapy.
The aim of this study was to evaluate the utility of reimaging rectal cancer post-CRT (chemoradiotherapy) with magnetic resonance (MR) imaging of the pelvis for local staging and computed tomography of thorax, abdomen, and pelvis (CT TAP) to identify distant metastases. ⋯ MR reimaging using standard protocols is of limited value in determining surgical approaches; a better modality of local restaging is required.
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Multicenter Study Comparative Study
One-millimeter cancer-free margin is curative for colorectal liver metastases: a propensity score case-match approach.
To investigate the influence of clear surgical resection margin width on disease recurrence rate after intentionally curative resection of colorectal liver metastases. ⋯ One-mm cancer-free resection margin achieved in patients with colorectal liver metastases should now be considered the standard of care.