Annals of surgery
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Randomized Controlled Trial Multicenter Study
The impact of postoperative complications on long-term quality of life after curative colorectal cancer surgery.
To investigate the effect that complications have on patients' long-term quality of life (QoL) after curative colorectal cancer surgery. ⋯ Postoperative complications have adverse effects on long-term QoL, particularly for Physical, Role and Social Functioning, and Body Image, as well as for Mobility, Self-care, and Pain/Discomfort. These findings should inform future preoperative counseling and health care planning.
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Randomized Controlled Trial Comparative Study
Outcome analysis of a decade-long experience of isolated hepatic perfusion for unresectable liver metastases at a single institution.
To evaluate outcomes of isolated hepatic perfusion (IHP) on isolated liver metastases (LMs). ⋯ IHP results in excellent response rates for patients with unresectable liver metastasis from solid tumors. Improved local control for CRC patients undergoing IHP-HAI may improve survival.
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Randomized Controlled Trial Multicenter Study
Long-term follow-up of a randomized controlled trial of Lichtenstein's operation versus mesh plug repair for inguinal hernia.
To compare long-term results of Lichtenstein's operation versus mesh plug repair for open inguinal hernia repair. ⋯ ClinicalTrials.gov Identifier: NCT01637818.
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Randomized Controlled Trial
A noise-reduction program in a pediatric operation theatre is associated with surgeon's benefits and a reduced rate of complications: a prospective controlled clinical trial.
We assessed the impact of a noise-reduction program in a pediatric operating theatre. ⋯ Spontaneous noise during pediatric operations attains the magnitude of a lawn mower and peaks resemble a passing truck. The sound intensity could be reduced by 50% by specific measures. This reduction was associated with a significantly lowered number of postoperative complications. The surgeon's benefits are idiosyncratic with "responders" experiencing marked improvements.
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Randomized Controlled Trial
Prospective randomized controlled trial of rabbit antithymocyte globulin compared with IL-2 receptor antagonist induction therapy in kidney transplantation.
The aim of this study was to determine the safety and efficacy of induction with rabbit antithymocyte globulin (RATG) compared with interleukin-2 receptor antagonists in a racially diverse kidney transplant patient population under modern immunosuppression. ⋯ RATG induction provides improved protection against early acute rejection in black renal transplant recipients, whereas sensitized patients do not seem to demonstrate a similar benefit from this therapy. This study is registered at Clinicaltrials.gov (NCT00859131).