Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jan 2022
Review Case ReportsA Case Report of Imatinib-induced Acute Heart Failure and Literature Review.
Patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GISTs) or acute lymphoblastic leukemia (ALL) are appropriate candidates for medical treatment using imatinib. Here, we report a case of imatinib-induced acute heart failure in a patient with ALL and retrospectively analyse the adverse reactions of imatinib. The patient was a 45-year man with Ph+ and bcr-abl positive (bcr-abl+) ALL. ⋯ A retrospective analysis of the adverse reactions in 100 cases of leukemia patients, who took imatinib in the past three years, indicated a rare incidence of congestive heart failure among those patients. Our experience in treating the patient suggests that brain natriuretic peptide levels and cardiac doppler examinations should be monitored closely in these patients. Key Words: Imatinib, Acute lymphoid leukemia, Acute heart failure.