Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Dec 2024
Deep Vein Thrombosis as a Harbinger of Malignancy in the Emergency Department.
To determine whether malignancy was discovered within one year of follow-up in patients with deep vein thrombosis (DVT) in the emergency department (ED). ⋯ Deep vein thrombosis, Malignancy, Emergency department, Venous Doppler ultrasound.
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J Coll Physicians Surg Pak · Dec 2024
Determination of the Late Postmortem Interval by Observing the Electrical Conductivity in Skeletal Muscles of Rats.
To determine the values of electrical conductivity (EC) of cadaveric skeletal muscles of male rats and their relationship with different postmortem intervals (PMI). ⋯ Postmortem interval, Electrical conductivity, Skeletal muscles, Postmortem changes, Muscle conductivity.
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J Coll Physicians Surg Pak · Dec 2024
Burnout among Medical and Dental Students: Prevalence, Determinants, and Coping Mechanisms.
To assess the burnout and resilience scores among medical and dental students and to identify the factors that affect burnout and resilience of the students. ⋯ Burnout, Resilience, Medical students, Exhaustion.
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J Coll Physicians Surg Pak · Dec 2024
Observational StudyC5aR2 in Breast Cancer and Its Relationship with Clinicopathological Features.
To determine the relation between C5aR2 and clinicopathological parameters of breast cancer. Study Design: Observational study. Place and Duration of the Study: Department of Histopathology, PNS Shifa Hospital, Karachi, from January to June 2023. Methodology: One hundred and twenty-eight women, aged 24-90 years with histologically proven diagnosis of breast cancer, were included in the study. Immunohistochemistry (IHC) was performed to evaluate the C5aR2 expression by its percentage and intensity. The C5aR2 staining was observed in membranes and/or cytoplasm. The immunoreactive score (IRS) was obtained and its association was analysed with clinicopathological parameters of breast cancer. SPSS version 27 was used to analyse the data. Results: The C5aR2 expression was higher in tumour cells (90.6%) compared to stromal cells (53.1%), predominantly exhibiting cytoplasmic localisation. Higher C5aR2 expression was observed in older age groups, higher-grade tumours, and ER/PR/HER2 and HER2 positive tumours. Moreover, tumours with poor treatment response also showed increased C5aR2 expression compared to those with good treatment response. Although no significant association was identified between C5aR2 expression and Ki67, increased C5aR2 expression has been found in tumours with high cell proliferation rates. ⋯ Breast cancer, C5aR2, Cancer associated fibroblasts, Immunohistochemistry, Ki67.