Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
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Randomized Controlled Trial
Effect of dexamethasone on glucose homeostasis in normal and prediabetic subjects with a first-degree relative with type 2 diabetes mellitus.
To determine the effect of a single 8-mg orally administered dose of dexamethasone or placebo on glucose and insulin homeostasis, during an oral glucose tolerance test (OGTT) performed before and 24 hours after the administered dose. ⋯ In a study population in which all subjects had at least one first-degree relative with type 2 diabetes mellitus, those with prediabetes were more insulin resistant and had a lower disposition index than did subjects with NGT. Subjects with prediabetes also had a pronounced decrease in disposition index when challenged with a single 8-mg orally administered dose of dexamethasone.