Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
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Ann Noninvasive Electrocardiol · Nov 2013
Randomized Controlled TrialLomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.
The aim of this study was to assess the effect of high plasma levels of lomitapide and its main metabolite on ECG parameters. ⋯ Lomitapide does not have an effect on cardiac repolarization. The study's ability to detect small QTc changes was demonstrated with both moxifloxacin and ketoconazole.