Journal of evaluation in clinical practice
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Testing of new drugs through clinical trials is essential in efforts to increase generalizable knowledge. Little is known about the medical students' perception of their participation as research subjects in clinical trials. The aim of this study was to examine the willingness and attitudes of medical students towards participation as volunteer subjects in clinical trials. ⋯ Most students were undecided about their participation, but their attitudes towards clinical trials in general were positive. Positive attitudes towards clinical trials did not uniformly translate to the willingness for personal participation. Promotion of blood donation and volunteering at universities could help to increase the interest in clinical trials as volunteer subjects.
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Advanced practice physiotherapy roles (Advanced Physiotherapy Practitioners [APPs] and First Contact Physiotherapists [FCPs]) are pivotal in supporting patients to manage their musculoskeletal (MSK) conditions. Having a greater understanding of how decisions are made by these practitioners will inform competency frameworks and improve the provision of patient-centred care. ⋯ The responses in this study showed that overall APPs and FCPs have good knowledge of SDM and report routine use of collaborative and patient-led decision-making approaches.
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Pathology services represent an ideal setting to integrate absolute cardiovascular disease (CVD) risk estimation when patients attend for routine cholesterol testing. This study aimed to explore the process of implementing CVD risk estimation into point-of-care service delivery by pathology staff to inform future implementation and sustainability. ⋯ Implementing CVD risk estimation into point-of-care pathology services required an understanding of the core implementation components specific to each context, and for implementation strategies to be targeted to the individual and organisational contexts. The generated programme logic model may be useful in guiding future implementation endeavours within these services and aiding the selection of apt implementation strategies.
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Hypothesis testing is integral to health research and is commonly completed through frequentist statistics focused on computing p values. p Values have been long criticized for offering limited information about the relationship of variables and strength of evidence concerning the plausibility, presence and certainty of associations among variables. Bayesian statistics is a potential alternative for inference-making. Despite emerging discussion on Bayesian statistics across various disciplines, the uptake of Bayesian statistics in health research is still limited. ⋯ Health researchers should supplement frequentists statistics with Bayesian statistics when analysing research data. The overreliance on p values for clinical decisions making should be avoided. Bayes factors offer a more intuitive measure of assessing the strength of evidence for null and alternative hypothesis.
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Retraction Of Publication
Retraction: "How the adverse effect counting window affected vaccine safety calculations in randomised trials of COVID-19 vaccines".
RETRACTION: "Re: How the adverse effect counting window affected vaccine safety calculations in randomised trials of COVID-19 vaccines," by H. Daungsupawong and V. ⋯ The above article, published online on 26 February 2024 in Wiley Online Library, in Volume 30, Issue 4, has been retracted by agreement between the journal Editor-in-Chief, Karen Grimmer and Michael Loughlin; and John Wiley & Sons Ltd. The retraction has been agreed as this Letter to the Editor lacks relevant scientific discussion and the statements in this letter are not sufficiently supported by references to the literature.