Biochemia medica : časopis Hrvatskoga društva medicinskih biokemičara
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Biochem Med (Zagreb) · Feb 2021
Comparative StudyEvaluation of a new equation for estimating low-density lipoprotein cholesterol through the comparison with various recommended methods.
The accurate estimation of low-density lipoprotein cholesterol (LDL) is crucial for management of patients at risk of cardiovascular events due to dyslipidemia. The LDL is typically calculated using the Friedewald equation and/or direct homogeneous assays. However, both methods have their own limitations, so other equations have been proposed, including a new equation developed by Sampson. The aim of this study was to evaluate Sampson equation by comparing with the Friedewald and Martin-Hopkins equations, and with a direct LDL method. ⋯ The Sampson equation may represent a cost-efficient alternative for calculating LDL in clinical laboratories.
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Biochem Med (Zagreb) · Feb 2021
Comparison of diagnostic accuracy for eight SARS-CoV-2 serological assays.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests have been suggested as an additional diagnostic tool in highly suspected cases with a negative molecular test and determination of seroprevalence in population. We compared the diagnostic performance of eight commercial serological assays for IgA, IgM, and IgG antibodies to the SARS-CoV-2 virus. ⋯ There is high variability between IgM assays independently of the assay format, while IgG assays showed moderate to perfect agreement. The appropriate time for testing is crucial for the proper immunity investigation.