Archives of disease in childhood
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Meta Analysis
Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review.
To compare the efficacy and safety of theophylline or aminophylline for prevention of acute kidney injury (AKI) in neonates and children. ⋯ A single dose of prophylactic theophylline helps in prevention of AKI/severe renal dysfunction in term neonates with severe birth asphyxia (moderate quality evidence) without increasing the risk of complications and without affecting all-cause mortality (very low-quality evidence).