Archivos argentinos de pediatría
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Arch Argent Pediatr · Dec 2020
ReviewRecommendations for the initial management of multisystem inflammatory syndrome temporally related to COVID-19, in children and adolescents.
Multisystem inflammatory syndrome temporally related to COVID-19 in children and adolescents is a clinical presentation of SARS-CoV-2 infection. It shares some features with Kawasaki disease, toxic shock, sepsis, macrophage activation syndrome, and myocarditis. Few publications have addressed its initial management, which is similar to that proposed for septic shock. This review analyzes such approach based on the characteristics typical of multisystem inflammatory syndrome related to COVID-19 in accordance with the paradigm of an "institutional practice guideline" and suggests therapeutic approach strategies, including early detection, stabilization, referral, specific treatment, and process analysis.
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Arch Argent Pediatr · Feb 2021
Review Case ReportsMultisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients.
Multisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. ⋯ Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.
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Arch Argent Pediatr · Jun 2021
Impact of the SARS-CoV-2 pandemic on the administration of vaccines as per the national immunization schedule in children younger than 2 years.
The reduction in the number of visits to health care centers since the onset of the SARS-CoV-2 pandemic may affect mandatory vaccination. ⋯ As of the second fortnight of March 2020, vaccinations dropped by 64.2 % compared to the same period of the previous year.
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Arch Argent Pediatr · Feb 2021
Case Reports[SARS-CoV-2 Detection in cerebrospinal fluid in a pediatric patient. Case report].
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, is an emerging infectious agent. The knowledge of both its infectivity mechanisms and the possible complications and specific treatments is the subject of constant research. ⋯ We describe the clinical case of a 2-month-old patient who consulted for fever without a focus with detection of SARSCoV- 2 by reverse transcription polymerase chain reaction in nasopharyngeal secretions and cerebrospinal fluid. The infant presented good evolution, with resolution of the fever and without compromise or neurological manifestations.
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Arch Argent Pediatr · Jun 2020
Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children.
HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status. ⋯ There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.