Health technology assessment : HTA
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Health Technol Assess · Jun 2014
Randomized Controlled Trial Comparative StudyUnited Kingdom Oscillation Study: long-term outcomes of a randomised trial of two modes of neonatal ventilation.
One in 200 infants in the UK is born extremely prematurely, i.e. before 29 weeks of gestation. Seventy-five per cent of such infants survive, but many have long-term respiratory and/or functional problems. ⋯ Follow-up at 11-14 years of age of extremely prematurely born infants entered into a randomised trial of HFO versus CV has demonstrated significant differences in lung function in favour of HFO. There was no evidence that this was offset by poorer functional outcomes; indeed, HFO children did better in some school subjects. It will be important to determine whether or not these differences are maintained after puberty as this is the last positive effect on lung function.