Health technology assessment : HTA
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Health Technol Assess · Nov 2018
Randomized Controlled Trial Multicenter Study Clinical Trial Observational StudyPrognostic models for identifying risk of poor outcome in people with acute ankle sprains: the SPRAINED development and external validation study.
Ankle sprains are very common injuries. Although recovery can occur within weeks, around one-third of patients have longer-term problems. ⋯ Further model refinement, including recalibration or identifying additional predictors, may be required. The effect of implementing and using either model in clinical practice, in terms of acceptability and uptake by clinicians and on patient outcomes, should be investigated.
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Health Technol Assess · Nov 2018
Randomized Controlled Trial Multicenter StudyCombining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT.
Depression is usually managed in primary care and antidepressants are often the first-line treatment, but only half of those treated respond to a single antidepressant. ⋯ Treatment-resistant depression remains an area of important, unmet need, with limited evidence of effective treatments. Promising interventions include augmentation with atypical antipsychotics and treatment using transcranial magnetic stimulation.