Health technology assessment : HTA
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Health Technol Assess · Sep 2018
Randomized Controlled Trial Multicenter StudyRestricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT.
There has been no randomised controlled trial (RCT) of fluid bolus therapy in paediatric sepsis in the developed world despite evidence that excess fluid may be associated with harm. ⋯ Further observational work is required to determine the epidemiology of severe childhood infection in the UK in the postvaccine era.